Groundsel was used by early herbalist to treat painful menstruation. It was later used as a laxative or purgative and was thought to cure stomach ache. The plant was used as an emetic.
Biliousness was treated with it. It was also used in cases where the body temperature had to be lowered.
Externally, groundsel was used in hot poultices on boils and in cold poultices for nursing mothers to relieve engorged breasts. It was also used externally for cleaning wounds and healing chapped hands as well as for treating bleeding gums.
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